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Of such Atgs, Beclin 1, the mammalian ortholog of yeast Atg6, interacts with class III PI3K (also named Vps34) and thus plays a very important role while in the initiation of autophagosome formation during autophagy7. Beclin 1 is the very first autophagy-connected tumor suppressor gene documented thus far, and it's been proven to promote autophagy

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